Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Exacerbation of N-nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress

Psychological stress contributes to increased susceptibility to a number of diseases including cancer. The present study was designed to assess the effect of chronic unpredictable stress on N-nitrosodiethylamine induced liver toxicity in terms of in vivo antioxidant status and DNA damage in Swiss albino mice. The animals used in this study were randomized into different groups based on the trea...

متن کامل

oxidative stress and dna damage in mice kidneys exposed to cadmium chloride

background: cadmium is one of the most toxic heavy metals in our environments having a very strong ability to accumulate in body organs especially in kidney. our aim of this study is to determine of the genotoxicity and cytotoxicity in mice kidneys exposed to cadmium. material and method: in this study we sacrificed 30 male mice and randomly divided into 2 different groups (control& case). ever...

متن کامل

Antidepressant effects of hydroalcoholic extract of Alpinia officinarum rhizome on chronic unpredictable stress induced depression in BALB/c mice

Background: Alpinia officinarum is an aromatic plant that show some neuroprotective functions in animal models. Objective: This study aimed to evaluate the antidepressant effects of hydroalcoholic extract of A. officinarum rhizome using two behavioral models. Methods: Forty male BALB/c mice were randomized to four groups. All studygroups underwent three weeks of daily chronic unpredictable str...

متن کامل

P-62: Damage to Sperm DNA and Protamine Deficiency Induced by Risperidone in NMRI Mice

Background: Antipsychotic medication use is a common cause of hyperprolactinemia that shown to have adverse effects on male fertility. Risperidone is a combined serotonin/dopamine receptor antagonist that can cause elevations in prolactine level. Its mechanism of cytotoxic effects on testicular germ cells is not fully understood. In the present study we sought to elucidate the impact of risperi...

متن کامل

Antioxidant Effect of CoQ(10) on N-nitrosodiethylamine-induced Oxidative Stress in Mice.

The antioxidant effect of CoQ(10) on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ(10) and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ(10) groups. However, the increase ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2017

ISSN: 1663-9812

DOI: 10.3389/fphar.2017.00360